Research and capacity building for control of neglected tropical diseases: The need for a different approach
Publication: PLoS, 31 May 2011
Author(s): Thomas Kariuki, Richard Phillips, Sammy Njenga, Ole F. Olesen, Paul R. Klatser, Riccardo Porro, Sarah Lock, Maria Hermínia Cabral, Martina Gliber, Detlef Hanne
Full article
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Laboratory-based diagnosis of pneumococcal pneumonia: State of the art and unmet needs
Publication: Clinical Microbiology, May 2011
Author(s): G. Vernet, S. Saha, C. Satzke, D. H. Burgess, M. Alderson, J.-F. Maisonneuve, B. W. Beall, M. C. Steinhoff and K. P. Klugma
Abstract
In view of the increasing use of pneumococcal vaccines, especially in the developing world, there is a need for appropriate diagnostics to understand the aetiology of pneumonia, to define the burden of pneumococcal disease, and to monitor vaccine efficacy and effectiveness. This article summarizes a meeting on the diagnosis, detection and serotyping of pneumococcal disease organized by PATH and Fondation Mérieux (18–20 October 2009, Fondation Mérieux Conference Centre, Les Pensières, France).
Workers and experts met to discuss the gaps in the microbiology-based diagnosis of Streptococcus pneumoniae disease, with special emphasis on pneumonia. The meeting was designed to evaluate the state of the art of pneumococcal diagnostics and serotyping methodologies, identify research and development needs, and propose new guidelines to public health authorities to support the introduction of vaccines.
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European HIV / AIDS Funders Group Annual Report 2007
European philanthropic support to address HIV / AIDS in 2007
The European HIV / AIDS Funders Group has released its annual report on resource flows for HIV / AIDS from European funders. The publication is entitled 'European Philanthropic Support to Address HIV / AIDS in 2007' and has gathered data on HIV / AIDS-related philanthropic expenditures in 2007 from 39 organisations. The report includes total expenditures and total commitments figures, as well as a breakdown of funds by geographical region, the breakdown of funds by intended use, the top three main population groups to which their funding was directed, and their forecast for funding increases or decreases in 2008.
Annual report 2007
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Partnerships to support global health
Publication: Microbe, 2008
Author(s): Arin Farrington
Abstract
ASM is involved with a variety of international partners supporting clinical labs and other global health activities. The Maputo Declaration provides guidelines for setting up sustainable lab-based testing to diagnose three high-priority infectious diseases, namely tuberculosis (TB), HIV / AIDS, and malaria. Disparate public health issues can and should be approached simultaneously, taking advantage of the expanded lab capacity to target many different infectious diseases.
Les orthoréovirus: virus orphelins ou pathogènes chez l'homme?
Publication: Virology, July - August 2008 (Review)
Author(s): L. Ouattara, G. Paranhos-Baccalà, F. Komurian-Pradel
Abstract
The orthoreoviruses are segmented double strand RNA viruses and are the most abundant viruses in nature. Three main serotypes are known, named 1, 2 and 3. The designation 'reovirus' is the acronym for 'respiratory enteric orphan virus', expression underlining their respiratory and enteric origin and the fact that they are not associated with well defined clinical disease. Nevertheless, strains of orthoreoviruses have been isolated from several cases of symptomatic diseases in human, namely diseases of the central nervous system such as encephalitis and meningitis sometimes leading to patient death. These different cases show that orthoreoviruses could be pathogenic, causing fatal diseases. Orthoreoviruses infection in animals induces also several diseases. Indeed, according to the inoculation route and the serotype of inoculated strain, encephalitis or hepatitis can be observed. The RNA segments M2 and S1 seem to be involved in this neurovirulence property and are on the basis of cellular mechanisms, such as virus entry, virus replic.
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