Vaccine efficacy reflects the proportionate reduction in disease incidence between unvaccinated and vaccinated individuals. While vaccines are typically licensed on the basis of demonstrated efficacy, the ultimate goal of vaccination is to achieve a significant public health impact in addition to the prevention of infection in an individual. In this respect, there is a need to provide a broader perspective that encompasses the capacity of a vaccination program to reduce microbial transmission, avert disease, disability and premature deaths, and to lessen the pressure on health system and to reduce health inequities between populations. These issues are particularly relevant for some of the newer vaccines (e.g., rotavirus, dengue, and malaria vaccines) that demonstrate lower efficacy in high burden settings than traditional vaccines, but nevertheless could have a substantial overall public health impact in these settings.
Beyond Efficacy: The full public health impact of Vaccines in addition to efficacy measured in trials
Fondation Mérieux event
22 - 24 June 2015, Les Pensières, Annecy (France)