Fondation Merieux

A family foundation dedicated to fighting infectious diseases

International conference on aminoacyl-tRNA synthetases

20 May 2008, Annecy (France)

The next International Conference on Aminoacyl-tRNA synthetases (aaRS2008) entitled from 'Basic Mechanisms to Systems Biology' will be held between 7–11 September 2008 at Les Pensières, Veyrier du Lac, France.

Aminoacyl-tRNA synthetases fulfil a uniquely fundamental role in molecular biologyby defining the genetic code which links amino acids to codons. Further to this crucially important task in protein synthesis, synthetases also play other significant roles in the cell, ranging from signaling to viral assembly and antibiotic resistance. The objective of this meeting is to review new results in all these different areas and to develop a broad system biology framework for future synthetase research.

The topics include:

  • Structure of aminoacyl-tRNA synthetases and their substrate complexes;

  • Fundamental mechanisms of aminoacylation and proof reading by aminoacyl-tRNA synthetases;

  • tRNA recognition by aminoacyl-tRNA synthetases;

  • Evolution of aminoacyl-tRNA synthetases, synthetase-like proteins and tRNAs;

  • Multi-synthetase complex in higher eukaryotes;

  • Synthetases and cellular networks;

  • Non-canonical functions of aminoacyl-tRNA synthetases;

  • Aminoacyl-tRNA synthetases and disease;

  • Aminoacyl-tRNA synthetases as antibiotic targets;

  • Engineering of Aminoacyl-tRNA synthetases to expand the genetic code.

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