This project conducts molecular typing of tuberculosis strains in Laos to provide information about circulating lineages and genotypes in order to improve the efficacy of disease control plans.
Context and scientific objectives
There is little available data on the molecular epidemiology of tuberculosis in Laos. Given the significance of trade and travel between Cambodia, Vietnam, and Laos, it is likely that the Beijing family strains (associated with a higher rate of resistance) are currently spreading through Laos, as recently shown in Vietnam.
Data that is collected will indicate which lineages are circulating and will offer a baseline for future epidemiological studies. The final objective is to improve the efficacy of control measures used by national institutions.
- Establishment of biobanks for tuberculosis strains and related clinical data
- Typing of MIRU-VNTRs, spoligotyping of the biobank, and Sanger sequencing of the genes involved in resistance to first-line antibiotics
- Consolidation of data from the three countries and analysis of profiles
- Mérieux Foundation
- Infectious Diseases and Vectors: Ecology, Genetics, Evolution and Control, IRD Montpellier, France
- National Institute of Hygiene and Epidemiology, Hanoi, Vietnam
- Institut Pasteur of Cambodia, Phnom Penh, Cambodia
- Lao Christophe Mérieux Infectiology Center, Laos
- Emerging Pathogens Laboratory, Lyon, France