Mérieux Foundation event

Arboviruses: A Global Public Health Threat

20 - 22 June 2018 - Les Pensieres Center for Global Health, Veyrier-du-Lac (France)

Summary

Arboviruses: A Global Public Health Threat group

In retrospect, announcements of a dengue pandemic in the 1990s were a sentinel call to action in the fight against a range of emerging and re-emerging arboviruses.

With the recent outbreak of neurological disorders and neonatal malformations associated with Zika virus in Latin America, the yellow fever outbreaks in Angola and Brazil, West Nile Virus in North America, the not-too-distant emergence from sub-Saharan Africa and global spread of chikungunya virus with a relatively recent arrival in the Americas, and the on-going and deepening dengue pandemic in the tropics and especially Asia, arboviruses and specifically flaviviruses are in the news and at the top of social, political and public health agendas.

These events establish an urgency and raise awareness of the need for integrated control and prevention strategies. These strategies focus on vector control, environmental management, personal protection, social mobilization and political will, case ascertainment and management, surveillance including laboratory confirmation, and vaccination.

It is widely recognized that no single strategy alone can fully address the problem. Timely access to clinical services and appropriate care can reduce mortality dramatically. Vaccines are widely available to protect against japanese encephalitis and yellow fever. The first dengue vaccine was licensed in 2015 and several more candidates are under development. Zika vaccine candidates are in early stages of development and progressing with full support. While diagnostics are available for surveillance and research, recent events have highlighted the need for differential diagnostics, and the need for point-of-care rapid diagnostic tests. Following the application of rigorous evaluations, there is increasing awareness of the efficiency of various prevention strategies against disease. Progress is being made.

Urbanisation, poverty and international trade and travel are widely recognized as contributors to these emerging and re-emerging arboviruses and the diseases they cause. The impact of climate change is also widely touted, although the relationship is complex.

The aim of this meeting was to raise awareness and advance the discussion on these topics.

Partnership for Dengue Control (PDC) website

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Program

Wednesday, June 20

Thursday, June 21

Friday, June 22

Session 1: Epidemiology, diagnostic and surveillance

Chair: Usa THISYAKORN

  • 8:30 - 8:50

    Surveillance for arboviral diseases

    Duane GUBLER

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  • 9:05 - 9:25

    Yellow fever: the current Brazilian outbreak and response

    João Bosco SIQUEIR Jr

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  • 9:40 - 10:00

    The interplay between different flaviviruses: overview and results from Brazil

    Mauricio Lacerda NOGUEIRA

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Session 2: Disease update: emphasis on the exemple of Zika

Chair: Mauricio Lacerda NOGUEIRA

  • 10:45 - 11:05

    Zika virus transmission as an endemic disease in Thailand

    Rome BUATHONG

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  • 11:20 - 11:40

    Evolution of emergence and expansion of Zika virus: difference from Dengue and Chikungunya

    Nikos VASILAKIS

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  • 11:55 - 12:15

    The complex relationship between the emerging flaviviruses: Dengue and Zika

    Michael GAUNT

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  • 14:35 - 14:55

    Stress-induced unfolded protein response contributes to Zika virus-associated microcephaly

    Marc LECUIT

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  • 15:10 - 15:30

    Progress and hurdles to a safe and effective Zika vaccine

    Anna DURBIN

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  • 16:15 - 16:35

    The origins and catalyst for formation of CEPI; CEPI’s priorities

    George THIRY

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  • 16:50 - 17:10

    EU-Research Programmes on Zika

    Annelies WILDER-SMITH

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Session 3: Vectors biology and control

Chair: Nikos VASILAKIS

  • 8:30 - 9:00

    Overview of Aedes aegypti biology and interactions with dengue and Zika viruses

    Louis LAMBRECHTS

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  • 9:15 - 9:35

    Wolbachia: how to optimise and sustain its promise of control of Aedes and Aedes-borne viruses

    Scott RITCHIE

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Session 4: Dengue Vaccines

Chair: Duane GUBLER

  • 10:20 - 10:40

    Dengue vaccines: status and future

    In-Kyu YOON

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  • 10:55 - 11:15

    CYD-TDV - Dengvaxia® - clinical update

    Christopher NELSON

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  • 11:30 - 11:50

    The first licensed tetravalent dengue vaccine: deliberations on its use

    Annelies WILDER-SMITH

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  • 14:00 - 14:20

    Dengue diagnostics update

    Elizabeth HUNSPERGER

  • 14:35 - 14:45

    Rapid and ultrasensitive detection of pathogens for early and late post-exposure countermeasures

    Fransisco VEAS

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