50 years in the fight against infectious diseases 1967 – 2017

Correlates of enteric vaccine-induced protection 2016

21 - 23 March 2016 - Les pensieres, Veyrier du Lac (France)


The ability to assess the protective efficacy of a vaccine by measuring the proportion of vaccinees who generate a particular immune response, without having to measure clinical outcomes, has significant advantages. The availability and quality of such substitute endpoints are important for vaccine development, licensure and effectiveness monitoring. A better understanding of the interrelationships between vaccination, the immune response, protection, and clinical outcomes is thus of interest not only to regulatory and public health authorities but also to microbiologists, immunologists, epidemiologists and statisticians [WHO/IVB/13.01].

The correlates of vaccine-induced immunity are a subject of continued interest for both theoretical and practical reasons. The latter include the need to evaluate the consistency of vaccine production; the susceptibilities of individuals and populations after vaccination; the validation of vaccines for which placebo-controlled efficacy trials are no more ethical (e.g. rotavirus vaccines), as when apriorgeneration vaccine is already licensed; and the licensure of combination vaccines.


Monday 21 March

Tuesday 22 March

Wednesday 23 March

  • 16:30 - 17:05

    Keynote address 1: Correlates of protection induced by vaccines with emphasis on enteric vaccines

    Stanley PLOTKIN

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  • 18:35 - 18:55

    Correlates of protection against enteric infections: What can be learned from polio vaccination?

    Nicholas GRASSLY

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Session 1 Workshop: novel approaches to correlate mucosal immune responses with protection in humans


  • 08:30 - 08:45

    Introduction to the workshop: intestinal B and T cells “homing”


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  • 09:35 - 09:55

    Th1, Th17 and T follicular helper cell responses to oral vaccination


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Session 2 Case studies I: correlates of protection: cholera, ETEC, typhoid and shigella

David SACK & Roger GLASS

  • 11:05 - 11:25

    Immune protection in cholera and immune response to oral cholera vaccination: knowledge from challenged volunteer model

    Myron LEVINE

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  • 14:30 - 14:50

    Mucosal immune response and correlates of protection against ETEC

    Firdausi QADRI

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  • 15:05 - 15:25

    Immune response and correlates of protection against typhoid

    Marcelo SZTEIN

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  • 16:15 - 16:35

    Immune response and correlates of protection against shigella

    Dani COHEN

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  • 16:50 - 17:05

    Correlates of protection from campylobacter: the known unknowns


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Session 3 Case studies II: correlates of protection: rotavirus, norovirus and hepatitis A


  • 17:20 - 17:40

    Current status of rotavirus vaccine and the value of a correlate of protection

    Umesh PARASHAR

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  • 17:55 - 18:15

    Immune response and protection against rotavirus: lessons from a birth cohort studies

    Gagandeep KANG

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  • 8:30 - 18:50

    Rotavirus immune responses and correlates of protection

    Manuel Franco

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Session 3 Continued

  • 08:30 - 08:50

    Mechanisms of protective immunity to hepatitis A

    Stephen FEINSTONE

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  • 09:05 - 09:25

    Immune response and correlates of protection from norovirus: lessons from challenge studies and clinical trials

    Robert ATMAR

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  • 09:40 - 10:00

    Norovirus diversity and immune-driven evolution: mechanisms of protection and implications for vaccine design


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Session 4 Regulatory aspects and further development of vaccines against enteric infections


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