17:15 - 17:30
Christophe LONGUET (Fondation Mérieux)
Mechanisms behind chronic infections (TB, HBV, HIV…) 2016
May 2 - 4, 2016 - Les pensieres, Veyrier du Lac (France)
When a pathogenic microorganism infects the human body, a dramatic activation of the innate and adaptive immune response occurs. In most cases, the interaction between the immune system and the pathogen result in clearance of the infection. However, some pathogens are capable of maintaining their presence, despite the severe attacks of the immune system, giving rise to persistent infection.
To remain and survive for a long period of time in its host, sometimes lifelong, the pathogens have evolved a range of elaborate immune-evasion strategies which may involve (1) hiding from the immune system, (2) interfering with the function of the immune system and/or (3) exploiting the immune system for their own benefit.
Many herpes viruses hide from the immune system by entering into a state known as latency in which the virus does not replicate. No viral proteins or peptides are presented on the surface of the infected cells and the cells cannot be eliminated. Other viruses, like VZV, invade neurons, which carry very little MHC I class molecules making it hard for the CD8 T cells to recognize infected cells.
Certain pathogens interfere with the cells of the immune system to block or dampen its actions. There are similarities in the immuno-modulatory mechanisms used by viruses and bacteria that have to overcome the same host immune system. Indeed, both classes of pathogens can inhibit complement, inhibit cytokines, interfere with TLRs, and block acquired immunity allowing long-term survival.
Pathogens can also exploit immune cells for their own benefit. This mechanism is demonstrated by HIV that replicates in CD4 T cells, EBV in B cells, and Dengue virus that infects Langerhans cells. Another example is M. tuberculosis which is taken up by macrophages but prevents the fusion of the phagosome with the lysosome, protecting itself from the bactericidal actions of the lysosomal contents./p>
This workshop will focus on immune-evasion strategies employed by three pathogens that are responsible for a very high medical burden, namely, tuberculosis, HIV and Hepatitis B infection. We will discuss the current understanding how these pathogens employ evasion mechanisms, and how to translate this knowledge to the development and rational design of new medicines and therapeutic vaccines.
Monday 2 May
Tuesday 3 May
Wednesday 4 May
Session 1 Continued
Session 2 Early host/pathogen interplay: impact on the outcome of infection
Session 3 Determinant of persistence in chronic infections
Session 4 Molecular mechanism of innate immune evasion
Session 5 Molecular mechanism of adaptive immune evasion
16:40 - 17:00
Induction of protective innate immune responses: lessons learned from HIV-2
Nicolas MANELDownload presentation
17:15 - 17:35
Metabolic regulation of immunity in chronic HBV infection
Laura PALLETDownload presentation
17:50 - 18:10
TB adaptive immune evasion
Simone JOOSTENDownload presentation
Session 6 Immune cell exhaustion in chronic infections and strategies to revert it
Session 7 Immunopathogenesis: mechanisms and therapeutic options
10:45 - 11:05
Robert THIMMEDownload presentation
11:55 - 12:15
NN cell and viral dynamics within lymph nodes during pathogenic and non pathogenic SIV infection
Michaela MULLER-TRUTWINDownload presentation
14:00 - 14:20
Sensing of HIV-1 entry triggers a type I interferon response in primary macrophages
Philippe BENAROCHDownload presentation
14:35 - 14:50
Understanding and Intervening in HIV Associated Tuberculosis
Robert WILKINSONDownload presentation
Cindy GRASSO - Conference Coordinator